Name: Prof. Dr. Dr. med. J. K. Habermann
Telefon: +49-451 500 40430
Fax: +49-451 500 2069
E-mails: Jens.Habermann@gmail.com

Ausbildung

P.D., Medical Faculty, University of Lübeck, Germany

M.D., Medical Faculty, University of Lübeck, Germany

Ph.D., Karolinska Institutet, Stockholm, Sweden (Prof. Gert Auer): “Colorectal Cancer: Genome, Transcriptome, and Proteome Dynamics”

Full license of Physician (State Office of Health and Occupational Safety, Schleswig-Holstein, Germany)

Berufserfahrung

Head, Laboratory for Surgical Research, Dept. of Surgery, University of Lübeck, Germany

Guest researcher, Karolinska Biomic Center (KBC), Karolinska Institutet, Stockholm, Sweden (Group Prof. Gert Auer)

Guest researcher, Genetics Dept., Center for Cancer Research (CCR), NCI, NIH, Bethesda, MD, USA (Group Dr. Thomas Ried)

Postdoctoral Fellowship, Genetics Department, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA (Dr. Thomas Ried)

Ph.D. candidate at the Unit of Cancer Proteomics, Dept. of Oncology and Pathology, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna, Stockholm (Prof. Gert Auer)

Junior House Officer, Department of Surgery, Medical University of Lübeck, Germany (Prof. Dr. Hans-Peter Bruch)

Associate at Siemens Health Services GmbH & Co.KG, Managed Healthcare Services, Erlangen, Germany (Dr. Klaus Wecker)

Doctoral Thesis, Laboratory for Surgical Research, Department of Surgery, University of Lübeck, Germany


Auszeichnungen

Poster Award, Surgical Research Symposium, Saarbrücken: “Potential serum biomarkers for colon cancer metastasis detection.”

Forum Innovative Therapies in Cancer (FIT) Award for best publication within the LifeScience region North-Germany

MSD-fellowship in oncology by MSD SHARP & DOHME GMBH

Von Langenbeck-Preis 2006, highest scientific award by the German Society of Surgery

Poster Award, European Society for Surgical Research: „Genomic imbalances and gene expression changes characterize genomic stable and unstable breast carcinomas.”

Research scholarship, Karolinska Institutet, Stockholm

State University Award 2002, Faculty of Medicine, Univ. of Lübeck

AACR-Award, Genentech: ”Comparison of CGH-profiles of ulcerative colitis-associated and sporadic colorectal cancer”

Keystone-Award, American Gastroenterological Association: “DNA-profile, Laminin-5 and Cyclin A expression as early markers for cancer risk in ulcerative colitis”

Poster Award, Surgical Research Symposium, Lübeck: “2-DE Cancer Proteomics: new strategies for tumor diagnostics.”

Research scholarship, Swedish Institute Stockholm, Sweden

Leonardo da Vinci scholarship, European Research Exchange Program

Reviewer

Bioinformatics
Cancer Research
Clinical & Experimental Metastasis
Expert Review of Anticancer Therapy
Gastroenterology
International Journal of Cancer
Molecular and Cellular Proteomics


Publikationen

A) Original Publikationen


(13) Roblick UJ, Bader FG, Hammarstedt L, Habermann JK, Hellman U, Becker S, Sundmäcker A, Gemoll T, Zimmermann K, Auer G, Munck-Wikland E. Proteomic Analysis of Protein Expression in Human Tonsillar Cancer. Acta Oncologica, accepted Dec. 2007.

(12) Roblick UJ, Bader FG, Lenander C, Hellman U, Zimmermann K, Becker S, Ǻke O, Alaiya A, Bruch H-P, Franzen B, Ried T, Auer G, Habermann JK. Undifferentiated pelvic adenocarcinomas: Diagnostic potential of protein profiling and multivariate analysis. Int J Colorectal Dis, accepted Dec. 2007.

(11) Habermann JK, Paulsen U, Roblick UJ, Upender M, McShane L, Korn E, Krüger S, Wangsa D, Bruch H-P, Auer G, Ried T. Stage-specific alterations of the genome, transcriptome, and proteome along the adenoma-carcinoma-sequence of colorectal carcinogenesis. Genes Chromosomes Cancer. 2007 Jan;46(1):10-26.

(10) Habermann JK, Roblick UJ, Luke B, Pietro D, Finlay WJ, Podust V, Roman J. Oevermann E, Schiedeck T, Homann N, Conrads T, Veenstra T, Burt S, Bruch H-P, Auer G, Ried T: Increased serum levels of complement C3a anaphylatoxin indicate the presence of colorectal tumors. Gastroenterology, 2006 Oct;131(4):1020-9; quiz 1284.

(9) Upender MB, Habermann JK, McShane LM, Korn E, Barrett JC, Difilippantonio MJ, Ried T. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in normal immortalized and diploid cancer cells. Cancer Res. 2004 Oct 1;64(19):6941-9.

(8) Korn E, Habermann JK, Upender MB,  Ried T, McShane LM. An objective method of comparing DNA microarray image analysis systems with application to a comparison of UCSF Spot and GenePix. Biotechniques. 2004 Jun;36(6):960-7.

(7) Roblick UJ, Hirschberg D, Habermann JK, Krueger S, Palmberg C, Becker S, Gustafsson M, Bruch HP, Franzen B, Ried T, Bergmann T, Auer G, Joernvall H. Sequential and specific alterations of the proteome during genesis and progression of sporadic colon cancer. Cell Mol Life Sci. 2004 May;61(10):1246-55.

(6) Habermann JK, Hellman K, Freitag S, Heselmeyer-Haddad K, Hellstrom AC, Shah K, Auer G, Ried T. A recurrent gain of chromosome arm 3q in primary squamous carcinoma of the vagina. Cancer Genet Cytogenet. 2004 Jan 1;148(1):7-13.

(5) Lenander C, Roblick UJ, Habermann JK, Ost A, Tryggvason K, Auer G. Laminin 5 gamma2 chain expression: a marker of early invasiveness in colorectal adenomas. Mol Pathol. 2003 Dec;56(6):342-346.

(4) Habermann JK, Upender MB, Roblick UJ, Kruger S, Freitag S, Blegen H, Bruch HP, Schimmelpenning H, Auer G, Ried T. Pronounced chromosomal instability and multiple gene amplifications characterize ulcerative colitis-associated colorectal carcinomas. Cancer Genet Cytogenet. 2003 Nov;147(1):9-17.

(3) Lenander C, Habermann JK, Ost A, Nilsson B, Schimmelpenning H, Tryggvason K, Auer G. Laminin-5 gamma 2 chain expression correlates with unfavorable prognosis in colon carcinomas. Anal Cell Pathol. 2001;22(4):201-9.

(2) Habermann J, Lenander C, Roblick UJ, Kruger S, Ludwig D, Alaiya A, Freitag S, Dumbgen L, Bruch HP, Stange E, Salo S, Tryggvason K, Auer G, Schimmelpenning H. Ulcerative colitis and colorectal carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment. Scand J Gastroenterol. 2001 Jul;36(7):751-8.

(1) Schimmelpenning H, Habermann J, Kruger S, Roblick UJ, Stange E, Ludwig D, Kujath P, Broll R, Auer G, Bruch HP. Ulcerative colitis-associated colorectal carcinoma. DNA ploidy as indicator of impending malignant transformation? Zentralbl Chir. 2000;125(11):880-7.

B) Reviews

(2) Habermann JK, Bader F, Franke C, Zimmermann K, Gemoll T, Fritzsche B, Ried T, Auer G, Bruch H-P, Roblick UJ. From the Genome to the Proteome – Biomarkers in Colorectal Cancer. Langenbecks Arch Surg. 2008 Jan;393(1):93-104.

(1) Habermann JK, Roblick UJ, Upender M, Ried T, Auer G. From genome to proteome in tumor profiling: molecular events in colorectal cancer genesis. Adv Exp Med Biol. 2006;587:161-77.

C) Buchkapitel

(5) J.K. Habermann, F.G. Bader, G. Auer, U.J. Roblick, H.-P. Bruch: Histopathologie, Tumor-klassifikationene und Prognosefaktoren. In Birth et al.: Intersdisziplinäres Managment von hepatobiliären und Pankreastumoren. Springer, in press.

(4) F.G. Bader, J.K. Habermann, G. Auer, H.-P Bruch, U.J. Roblick: Tumorbiologische und molekulargenetische Aspekte. In Birth et al.: Intersdisziplinäres Managment von hepatobiliären und Pankreastumoren. Springer, in press.

(3) Jens K. Habermann, Uwe J. Roblick, Madhvi Upender, Thomas Ried, Gert Auer: „Proteomics in Tumor Profiling - Molecular Events in Colorectal Cancer Genesis.“ Advances in Experimental Medicine and Biology, volume 587 (New Trends in Cancer for the 21st Century), by Antonio Llombart-Bosch, Vicente Felipo and José Antonio López-Guerrero. ISBN-10 1 4020 4966 8 Springer, September 2006.

(2) Habermann JK, Roblick UJ, Luke B, Pietro D, Finlay W, Podust V, Roman J. Oevermann E, Schiedeck T, Homann N, Conrads T, Veenstra T, Burt S, Bruch H-P, Auer G, Ried T: „Effectiveness of SELDI-TOF mass spectrometry for detection of serum markers for colorectal cancer.” German Society of Surgery, „Chirurgisches Forum 2006“ for experimental and clinical research, Forumband 2006, Volume 35, Page 119 – 121. ISBN 3-540-32480-1 Springer.

(1) J.K. Habermann, C. Lenander, U.J. Roblick, S. Krüger, H.-P. Bruch, T. Ried, G. Auer und H. Schimmelpenning: „DNS-Profil, Laminin-5 und Cyclin A Expression als frühe Marker für Karzinomentstehung bei Colitis ulcerosa.“ German Society of Surgery, „Chirurgisches Forum 2006“ for experimental and clinical research, Forumband 2001, Volume 30, Page 97-99. ISBN 3-540-41718-4 Springer.